The drug rimonabant, an inverse agonist at the CB1 receptor, reduces hunger and aids weight loss but was not approved due to causing suicidal ideation.

“when you give humans this has been done in europe this drug was never approved in the united states a drug called ramonaband it's an inverse agonist at the cb1 receptor which means it it technically binds to it but it blocks it so it blocks that cb1 receptor so you can give them this ramona band and it helps with hunger so it really helps them lose weight this would be a miracle drug for diabetes if it didn't cause people to commit suicide more because it turns out we need cannabinoid receptor signaling in the brain to have a uh a euthymic mood”