Restricting methionine for longevity is unnecessary; providing sufficient glycine is an alternative approach.

“then there's a series of studies where they gave glycine back to these mice and the glycine extended life right so this Metheny and glycine ratio is so important”

“people in the space get worried about Messiah and they want to refine and restrict for longevity and it's like no you don't have to restrict my thiamine just give them enough glice which we would have gotten ancestrally by eating connective tissue from animals”

“but then there's a series of studies where they gave glycine back to these mice and the glycine extended life right so this methionine glycine ratio is so important”

“then there's a series of studies where they gave glycine back to these mice and the glycine extended life right so this methionine glycine ratio is so important”

“So, this is quite interesting, and there are studies in rats and mice that show exactly this notion. This is a study from 1987. Many of these are old studies. The effect of dietary glycine on methionine metabolism in rats fed a high methionine diet.”

“The activities of methionine adenosyltransferase and cystathionine beta-synthase, were rather decreased while cystathionine gamma-lyase activity was not altered.”

“when you add glycine to these rats you can rescue much of this and you can extend the life of these rats”

“they won't tell you about the subsequent studies where they give the animals extra glycine and the lives are extended they're totally normalized when they have enough glycine to balance the methionine”

“Glycine Supplementation Extends Lifespan of Male and Female Mice.”

“well yes it does when you feed mice a crap diet but what they neglect to tell you is that you don't have to restrict methionine if you just give mice enough glycine something I've talked about many times in the past the idea that a glycine deficient diet will mimic excess methionine and you don't want excess methionine thankfully if you are eating meat with any amount of tendons or connective tissue ground into it like ground beef or all of the little connective tissue pieces of a steak then you will be getting enough glycine to balance your methionine you can also use things like collagen Etc so many of the proponents of meat restriction or methionine restriction will not tell you that simply supplementing glycine abrogates all of the negative effects of excess methionine”

“stream span restricting the amino acid methionine extends lifespan well yes it does when you feed mice a crap diet but what they neglect to tell you is that you don't have to restrict methionine if you just give mice enough glycine something I've talked about many times in the past the idea that a glycine deficient diet will mimic excess methionine and you don't want excess methionine thankfully if you are eating meat with any amount of tendons or connective tissue ground into it like ground beef or all of the little connective tissue pieces of a steak then you will be getting enough glycine to balance your methionine you can also use things like collagen Etc so many of the proponents of meat restriction or methionine restriction will not tell you that simply supplementing glycine abrogates all of the negative effects of excess methionine and again we're looking at mouse or rat models in contrived situations where these animals are fed a baseline diet of garbage”