Fat cells can signal muscles to become insulin resistant through the release of lipokines, a phenomenon that can occur during fasting states.

“our fat cells determine the insulin sensitivity of our muscles the fat cells are the director they're the conductor at the front of the train and when the fat cells release certain lipokines which are like hormones that are lipids into the blood they signal to the muscles to become insulin resistant”

“so in this state when you fast say you and i are out hunting and we're just going to eat what we kill and we're not eating for a few days this is normal human physiology just like our ancestors would have experienced we don't have any fruit right now we didn't find any beehives with honey we didn't even find any protein from an animal we're going into this fasting state our our adipocytes so our fat cells are going to release lipokines into the blood that are going to tell the muscles become insulin resistant refuse glucose because we need to spare that for the brain the testes the adrenals etc in the blood”