The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
in situations of insulin resistance whether it's physiologic or pathological the non-esterified fatty acids in the blood go up and this is a normal ketosis physiology but it's also physiology that happens in a pathological insulin resistant state like diabetes but the difference between them is that insulin is high in one state pathological diabetes and low in the other state which is the ketogenic state or the fasting state
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when you're doing ketosis when you're fasting if you're limiting carbohydrates you will see the free fatty acids go up and that's a physiologic insulin resistance response it's not the same as a pathologic insulin resistance but it is going to raise cortisol and that as Georgie talked about on previous podcasts and a little bit on this one when you're fasting when you're doing ketosis you will raise 11 beta hydroxy steroid dehydrogenase which is going to lead to excess cortisol
and that's a physiologic insulin resistance response it's not the same as a pathologic insulin resistance but it is going to raise cortisol and that as Georgie talked about on previous podcasts and a little bit on this one when you're fasting when you're doing ketosis you will raise 11 beta hydroxy steroid dehydrogenase which is going to lead to excess cortisol
Just to make that clear, in a fasted state or a low carb state, insulin is low and so you have more lipolysis. So free fatty acids will be higher. That's a that's a very common feature. This is the fasted state. Low insulin, high free fatty acids. In contrast, the fed state, especially if it has some carbs, now insulin has gone up. It's inhibited lipolysis and so free fatty acids will be down. This is the normal. It's one or the other. Unless the fat cells are insulin resistant.
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.