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Weekly · Sunday Morning

Five longevity claims.
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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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What causes diabetes? — Whalespan

Content›Video›What causes diabetes?…

What causes diabetes?

Paul Saladino11m · 2023-04-14

Claims Made

28

Claims Supported

28

Support Rate

100%

Support rate

28 of 28 claims supported

28 supported0 partial / not

Claims from this content

23

✓Well SupportedExcess free fatty acids in the blood cause peripheral tissues to become insulin resistant, which is the direct cause of diabetes.✓Well SupportedAspirin, by reducing cortisol, inflammation, and lipolysis, has been observed to cure diabetes temporarily in individuals, without causing lactic acidosis like metformin.✓Well SupportedIncreased free fatty acids during ketosis or fasting represent a physiological insulin resistance response that can raise cortisol.✓Well SupportedMetformin can cause lactate buildup by inhibiting steps in glucose metabolism, similar to the Randle cycle mechanism.Partially Supported

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Reversing obesity can cure diabetes, and limiting dietary fat intake can temporarily resolve diabetes without reversing obesity.

◐Partially SupportedHigh doses of sodium salicylate administered with large amounts of sweetened tea did not cause adverse effects even in type 1 diabetics.

◐Partially SupportedElevated cortisol is a partial cause of diabetes, obesity, and other conditions.

◐Partially SupportedConsuming one pound of candy sugar daily on top of a normal diet restored fertility even in morbidly obese men.

◐Partially SupportedProstaglandins can destroy the beta cells of the pancreas and cause type 1 diabetes.

◐Partially SupportedThe Randle cycle describes how glucose and fatty acids compete for cellular energy metabolism, inhibiting each other's utilization.

◐Partially SupportedLimiting fat supply or increasing relative glucose over fat may therapeutically affect diabetes caused by fat oversupply into the cell.

◐Partially SupportedAn oversupply of fatty acids in the bloodstream contributes to diabetes.

◐Partially SupportedAcipimox, a derivative of niacinamide, is an approved drug that inhibits lipolysis and can lower triglycerides, free fatty acids, and blood glucose in type 2 diabetic patients, even in the presence of obesity.

◐Partially SupportedOxidizing fatty acids increases the NAD to NADH ratio, inhibiting pyruvate dehydrogenase and slowing glucose metabolism.

◐Partially SupportedAspirin, through its metabolite salicylic acid, inhibits the enzyme 11 beta-hydroxysteroid dehydrogenase type 1, thereby reducing cortisol synthesis.

◐Partially SupportedA study administering 9-10 grams of aspirin daily for two weeks resulted in complete restoration of insulin sensitivity, blood glucose, and lipid profile in morbidly obese, pre-diabetic individuals.

◐Partially SupportedLimiting carbohydrates can trigger stress mechanisms, including increased cortisol due to elevated 11-beta-hydroxysteroid dehydrogenase.

◐Partially SupportedNon-esterified fatty acids increase during ketosis, fasting, or carbohydrate restriction.

◐Partially SupportedFeeding individuals with type 2 diabetes a diet of pure white rice and sugar can lead to the resolution of diabetes.

◐Partially SupportedThe drug acipox limits fat supply, thereby increasing the relative abundance of carbohydrates and producing similar effects to increasing glucose supply.

◐Partially SupportedExcess fat stores, particularly of polyunsaturated fatty acids, can cause inflammation and potentially diabetes.

◐Partially SupportedControlling a cell's metabolic flexibility can be achieved by manipulating the relative abundance of specific nutrients.

◐Partially SupportedIncreasing blood glucose supply may have a therapeutic effect on diabetes.