Oxidizing fatty acids increases the NAD to NADH ratio, inhibiting pyruvate dehydrogenase and slowing glucose metabolism.

“the cell says well in this emergency situation since I cannot get to oxygen which is the oxygen that can oxidize nadh back into NAD what other oxidizing agents do I have around me that can do this trick and that is peruvic so pyruvate acts as the emergence the oxidizing agents for nadh through an enzyme called lactate the hydrogenase so pyruvate oxidizes nadh back to NAD but in the process becomes lactate and coincidentally all the people with diabetes all the people with insulin resistance all the people with cancer cardiovasculars Etc they have higher than normal higher than optimal levels of lactic acid in the blood that demonstrates that there is an impediment of to the metabolism of glucose”