Excess free fatty acids in the blood cause peripheral tissues to become insulin resistant, which is the direct cause of diabetes.

“we know that increased levels of free fatty acids in the blood will lead to peripheral muscle insulin resistance metabolic dysfunction in general that's a bad outcome”

“and so what's if I understand what you're saying correctly it's it's all these excess fatty acids in the blood that do trigger peripheral insulin resistance their signaling to the muscles hey be insulin resistant to the brain to the liver if you have high levels of free fatty acids that's signaling insulin resistance to the body”

“ultimately it's the excess free fatty acids in the blood that cause the periphery to be resistant to insulin that is insulin resistance that is diabetes”

“it's very clear it's clear as day in the literature that it's not the blood glucose it's the free fatty acids”

“so it's dysfunction at the level of the adipocytes it's dysfunction at the level of our fat cells that's what causes diabetes because that's where these free fatty acids come from”

“But ultimately it's the excess free fatty acids in the blood that cause the periphery to be resistant to insulin that is insulin resistance status diabetes”

“the idea is that excess lipolysis excess free fatty acids in the blood trigger the periphery whether it's the muscles the liver the brain to become insulin resistant”