Calories from different sources like honey, sucrose, Coca-Cola, seed oils, and animal fats are not metabolically equivalent.

“we know that not all calories are created equally there are many good studies to suggest that certain fatty acids those being polyunsaturated omega-6 fatty acids like linoleic acid affect your physiology essentially in an endocrine like way differently than other fats if not all calories are the same if calories from honey are not the same as calories from sucrose table sugar or coca-cola then we have a burgeoningly complex interesting world of nutrition in which reductionism is death and reductionism will mislead us”