An excess of methionine without sufficient glycine can be harmful.

“and the actual burden of methionine and you're right as we know it's fairly easy to obtain methionine in a nose-to-tail carnivore diet by looking for connective tissue and that's found in its found in bones it's found in skeletal tendons it's found in collagen collagenous tissues chewy bits as westernized Americans we don't really want to eat these but we can get college and supplementation etc etc or just pure glycine as an amino acid it's probably beneficial in most contexts”

“I think the last brick that people might throw is the methionine content again very tied towards it's a core component of red meat or animal proteins or meth I mean being assisted with a higher mortality risk right and I think this probably goes until your nose-to-tail discussion where glycine supplementation or glycine content which is found in collagen basically reduces that that issue”

“if you have a nose to tail animal-based diet you're gonna have a very similar methionine to glassing ratio is if you have a vegan diet because you tend to have a very good balance between Matheny and glycine in plant foods you tend to have a very good balance between Matheny and glycine in whole animals but not in animal not in specific animal foods so muscle meat is very heavy and methionine relatively lower in glycine collagen which tissues such as bones and skin proteins are very rich in glycine have very little Matheny right so you got you can eat a plant where it's balanced or you can eat an animal where it's balanced but you can't pick and choose your animal parts and still retain the balance”

“but if you only eat muscle meat is there a potential that you will get too much methionine and not enough glycine I believe there is”

“so if you extrapolate we think like well what would you get if you were eating an animal nose-to-tail you might get for every one gram of thymine you might get 10 grams of glycine something like that or 8 grams of glycine so that ratio somewhere in that ballpark probably what we need as humans”

“the importance of a proper methionine glycine ratio and if we're eating animals nose tail and eating the connective tissue we're going to get glycine from that”

“Perhaps it is just that we need to make sure we are getting cuts of meat that have some tendons, some connective tissue, some fat, or eating some bone broth, or eating some collagenous tissue for our hair, skin, and nails that will give us enough glycine.”

“Remember, there's more glycine in there than there is methionine even at baseline.”

“so actually in meat you are getting more glycine than you are getting methionine so even eating meat as long as you're eating the connective tissue along with that meat i think you will be fine with the amount of glycine”

“i think that there is a lot to be said on that and you don't need to worry necessarily about getting enough glycine getting too much methionine as long as you are eating those detail and eating all of the animal”

“i think that as humans if we really want to understand how to how to drive the car what the owner's manual of the human body says it says get organs get connective tissue whether it's a bone broth get steaks get some sort of meat that's kind of chewy where there's ground beef get some collagen rich meat from an animal which is going to have much more glycine and much less methionine”

“collagenous tissues, bone broth, these types of things have 25, 30% glycine to much lower amounts of methionine, maybe 0.5%.”

“if you give animals, at least, and probably people, too much methionine without giving them enough glycine, that could be harmful. But, unfortunately, the longevity community conflates the presence of methionine in muscle meat with getting too much methionine.”

“So, I think that most humans living today are not getting enough cysteine or glycine because they're not eating enough animal products.”