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The Ancestral Health Solution feat Dr Paul Saladino Carnivore MD

PS

Paul Saladino2h 4m · 2020-04-23

Support Rate

73%

156 of 213 claims supported

Support rate

156 of 213 claims supported

156 supported57 partial / not

Claims from this content

174

Well SupportedAll vitamins and minerals found in plants can be obtained from animal sources in more bioavailable forms.Well SupportedIt is possible to obtain 60 mg of vitamin C daily by eating animal foods nose-to-tail, with liver being richer in vitamin C than muscle meat.Well SupportedRaw A2/A2 milk from Jersey or Guernsey cows is better tolerated by some individuals than A1/A2 milk.Well SupportedConsuming connective tissue provides glycine and helps maintain a healthy methionine-to-glycine ratio.Well SupportedAn excess of methionine without sufficient glycine can be harmful.

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Not Supported

Sulforaphane may scavenge iodine and act as a goitrogen, with toxic effects.

Well SupportedFruit is generally less toxic than leaves, seeds, nuts, grains, and legumes.

Well SupportedObtaining 2.6 grams of leucine from plant-based foods like lentils or beans requires consuming nearly half a pound of these foods.

Not SupportedFiber has not been shown to increase microbial diversity in the gut, and removing fiber does not decrease microbial diversity.

Well SupportedPaul Saladino eats two meals a day, typically his last meal before 4 p.m., skipping dinner.

Not SupportedThe idea that diverticulosis is caused by insufficient fiber intake is not supported by literature; higher fiber intake is associated with more diverticulosis.

Well SupportedStudies show resolution of idiopathic constipation when fiber is removed, contradicting the necessity of fiber for bowel movements.

Well SupportedOverfeeding mice with methionine shortens their lifespan, and restricting methionine in mice extends their lifespan.

Not SupportedVitamin C intake above 30-70mg per day may not provide benefits for humans and higher doses might be dangerous due to conversion to oxalate.

Well SupportedMice eating around the clock developed metabolic syndrome and insulin resistance, unlike mice eating the same amount of calories within an 8-hour window.

Well SupportedPlant foods exist on a spectrum of toxicity and can contribute to chronic disease.

Well SupportedEating early, at least 3-4 hours before bed, aligns with circadian biology, stabilizes blood glucose, improves sleep quality, and enhances overall metabolic health.

Not SupportedThe evidence for fiber preventing colon cancer is non-existent, with studies showing no change in the recurrence rate of colonic adenomas with fiber supplementation.

Well SupportedReducing meal frequency to two to three meals per day supports muscle protein synthesis, maintenance, strength, insulin sensitivity, and metabolic health.

Well SupportedCollagen from animal connective tissue can be fermented into short-chain fatty acids.

Well SupportedPlant molecules can have side effects when they interact with human biology.

Well SupportedA2 dairy may be less immunogenic than A1 dairy because A1 casein breaks down into beta-caseinorphin-7, associated with autoimmunity.

Not SupportedPlant molecules like curcumin and sulforaphane may have damaging collateral side effects that are not always disclosed.

Well SupportedMuscle meat is rich in tryptophan and methionine, while bone broth and collagenous tissues are rich in glycine, proline, and hydroxyproline.

Well SupportedDesiccated organ supplements can help people by providing an easy way to consume organs.

Well SupportedAnimal-source protein is significantly more utilizable by humans than plant-source protein, as indicated by the digestible indispensable amino acid score (DIAAS).

Well SupportedConsuming double the Recommended Dietary Allowance (RDA) of protein makes a significant difference in muscle maintenance compared to the RDA alone.

Not SupportedWestern physicians may be conditioned to focus on treating symptoms with medications rather than identifying root causes.

Well SupportedDr. Paul Saladino has used a nose-to-tail carnivore diet to reverse untreatable autoimmunity, chronic inflammation, and mental health issues in hundreds of patients.

Well SupportedSeeds, nuts, and legumes contain anti-nutrients and lectins and are designed to survive the digestive tract.

Not SupportedPaul Saladino experiences eczema, autoimmunity, and skin issues when consuming dairy, regardless of milk type.

Not SupportedFiber is not supported by clinical studies for constipation resolution.

Partially SupportedSulforaphane is highly oxidatively active and is released when Brassica vegetables are chewed as a plant defense mechanism.

Well SupportedOrgan supplements are taken to complement the nutritional profile of muscle meat.

Not SupportedCurcumin has potential side effects, including affecting the p53 tumor suppressor gene, thyroid oxido-reductase, topoisomerase 3, and potassium channels.

Well SupportedOlder individuals tend to experience less sleep, have reduced melatonin production, and sleep in more irregular time periods due to aging.

Well SupportedPlants contain toxins that can cause negative reactions in some individuals due to co-evolution with animals.

Well SupportedFermenting vegetables can degrade glucosinolates, potentially making plants less toxic and more tolerable.

Well SupportedHunter-gatherer tribes do not suffer from chronic diseases like diabetes, heart attacks, or autoimmune conditions, unlike Westernized populations.

Well SupportedThe amount of vitamin C required to prevent scurvy is significantly lower than the Recommended Daily Intake (RDI).

Well SupportedFasting promotes sirtuin activity, which aids in NAD recycling via AMPK, leading to a better circadian profile.

Partially SupportedChronic diseases like diabetes and insulin resistance are more common in Western societies than in indigenous cultures.

Partially SupportedIceland's diet is rich in animal products including fish, lamb, pork, fatty meats, and dairy.

Well SupportedIncreasing daily fasting times without reducing calories improves health and survival in male mice.

Partially SupportedCollagen and bone broth are valuable for humans, with collagen being referred to as the 'fourth macronutrient'.

Well SupportedMice lacking autophagy do not live longer on calorie restriction, indicating autophagy's role in longevity.

Partially SupportedConstant eating, eating at all hours, and snacking without a time-restricted feeding window keeps mTOR activated and prevents autophagy.

Well SupportedExercise, calorie restriction, and fasting are associated with increases in NAD+ levels in model mammals.

Partially SupportedIncreased intestinal permeability, suspected to be related to autoimmune diseases and cancer, can be reversed by a diet containing only meat, fat, and organ meat.

Partially SupportedSome individuals may develop scurvy on a carnivore diet if they consume only cured or non-fresh meats, but not if they eat fresh meat.

Well SupportedTime-restricted eating between 8:00 a.m. and 2:00 p.m. improves insulin sensitivity, lowers blood pressure, and reduces oxidative stress.

Partially SupportedStudies show no significant difference in glucose homeostasis or glucose control when comparing eating early versus late within a compressed eating window.

Partially SupportedIntermittent fasting triggers adaptive cellular responses that improve glucose regulation, increase stress resistance, suppress inflammation, and enhance DNA repair.

Partially SupportedThe transition from a hunter-gatherer diet to a pastoralist diet with more grains led to a decline in human health.

Not SupportedOverconsumption of fermented foods may lead to dental issues such as enamel erosion due to their acidity.

Not SupportedThe idea that abundant plant fiber is needed for high gut microbial diversity is unsupported by research.

Well SupportedAim for approximately 2.6 grams of leucine per meal, especially for aging individuals.

Well SupportedSarcopenia can be significantly slowed or prevented by lifelong activity, particularly resistance training.

Partially SupportedDairy and peanut butter can trigger asthma and eczema in children.

Partially SupportedThe 16:8 intermittent fasting method shows no significant difference in benefits compared to eating one meal a day, except potentially slightly more autophagy with one meal a day.

Partially SupportedNAD levels decrease with age due to oxidative stress, inflammation, and circadian misalignment.

Well SupportedChronic misalignment with circadian rhythms can cause problems, whereas occasional misalignment is not problematic if the body has sufficient resiliency.

Well SupportedCircadian rhythms weaken and flatten with age, leading to reduced daytime alertness and increased nighttime wakefulness.

Partially SupportedThe reactivation of the Notch2NL gene approximately three million years ago provided a caloric benefit that justified the energetic cost of a larger brain.

Well SupportedAutophagy is the cellular process of breaking down and recycling damaged components to maintain health and function, thought to extend lifespan.

Partially SupportedAnimal-based foods provide essential nutrients like preformed vitamin A and DHA/EPA, which are difficult to obtain from plant sources.

Partially SupportedFiber increases stool bulk and bowel movement frequency but does not significantly improve constipation-related pain, bleeding, or laxative need.

Partially SupportedEliminating plant polyphenols does not increase oxidative stress in humans and may improve oxidative stress parameters.

Partially SupportedIceland's nutrient-dense soil, derived from volcanic ash, may contribute to high population health through quality plants and animals.

Partially SupportedFasting every other day with calories below 500 may not yield the same autophagy results as longer fasts or time-restricted eating.

Partially SupportedIndividuals with insulin resistance assimilate less vitamin C, potentially requiring less for cellular uptake compared to insulin-sensitive individuals.

Not SupportedObtaining vitamin C from low-oxalate fruits is suggested.

Well SupportedTaking walks around meal times can aid digestion and help lower insulin levels.

Well SupportedSpecific phases of sleep impact growth hormone release, which is critical for metabolism, tissue repair, vitality, and longevity.

Partially SupportedIntermittent fasting provides health benefits, aligns the body with circadian rhythms, and has anti-aging effects beyond weight loss.

Well SupportedAvoid food for 1-2 hours after waking because melatonin is decreasing and cortisol is spiking.

Partially SupportedTime-restricted eating allows individuals to tolerate foods that might otherwise be problematic and is key to making metabolic systems function effectively.

Partially SupportedA low-carb ketogenic diet, including fatty cuts of steak, is satiating and facilitates fasting by utilizing body fat for energy.

Partially SupportedLeucine from plant foods may be half as effective as leucine from animal foods for triggering muscle protein synthesis.

Partially SupportedPEG 400 testing is considered the best available method for assessing leaky gut.

Partially SupportedMethionine is abundant in muscle meat and glycine is abundant in collagen.

Not SupportedWestern medicine's prevailing paradigm does not consider that most autoimmune and chronic diseases are reversible and fixable.

Partially SupportedVitamin A, C, D, E, selenium, zinc, and copper, often sourced from animals, are essential for a healthy immune system.

Partially SupportedEating bones, including those in bone broth or small animal bones, provides bioavailable calcium.

Partially SupportedConsuming bone broth made from the ends of long bones can provide calcium, and eating softened bones (like rib bones) is also a source of calcium and marrow.

Partially SupportedHumans may not produce sufficient glycine.

Partially SupportedAll pharmaceuticals have package inserts detailing side effects, and these molecules can have both good and bad net effects in humans.

Partially SupportedAncestral diets likely included plants primarily during times of starvation, not as major food staples.

Partially SupportedA robust immune system is achieved through metabolic health and nutrient repletion.

Well SupportedTime-restricted eating improves risk of metabolic disease, lowers body weight, cholesterol, triglycerides, blood glucose, insulin, and inflammatory biomarkers.

Well SupportedEating within a 2 to 8-hour time window can activate longevity genes and increase insulin sensitivity.

Well SupportedMeal timing is significant for long-term health effects due to its connection with circadian rhythms.

Partially SupportedHuman brains have decreased in size since peaking 10,000-20,000 years ago.

Partially SupportedEating processed foods that cause a significant insulin spike and then sitting sedentary has greater negative effects than eating steak, which does not cause a large insulin spike.

Partially SupportedDisruptions in circadian rhythms are linked to diseases like cardiovascular disease, hormonal imbalances, and sleep disorders.

Partially SupportedCircadian rhythms are regulated by environmental cues like light, food, physical activity, temperature, and magnetic frequencies.

Partially SupportedWait at least a few hours after waking up before eating, as cortisol levels rise in the morning.

Partially SupportedTime-restricted eating can protect against the negative effects of high-fat and obesogenic diets by mitigating side effects through a compressed eating window.

Partially SupportedCalorie restriction, through NAD metabolism, can reverse the negative association between aging and circadian rhythm robustness.

Limited ResearchVitamin C intakes above the amount needed to prevent scurvy may not provide additional antioxidant benefits in non-diabetic, non-insulin-resistant individuals.

Partially SupportedPlant molecules are foreign to human biology and are not essential vitamins or nutrients.

Not SupportedMalignant cancers can hijack autophagy to benefit their own growth.

Partially SupportedTime-restricted eating can reduce daily energy intake by approximately 650 calories without negatively affecting body composition or causing muscle loss.

Partially SupportedA 16-hour fasting/8-hour eating window allows for fat loss and muscle building.

Not SupportedConsistent sleep deprivation is linked to health problems like diabetes, insulin resistance, and Alzheimer's.

Partially SupportedTime-restricted eating leads to higher amplitude and robustness in circadian rhythms, which lowers inflammation and improves glucose tolerance and insulin sensitivity.

Limited ResearchThe benefit of consuming fermented bacteria is still an open discussion with no firm conclusion.

Partially SupportedPaul Saladino follows a low-carb ketogenic diet with nose-to-tail eating, some plants, vegetables, chicken, and eggs.

Not SupportedMedical school and residency programs do not adequately teach nutrition, integrative biochemistry, or the root causes of autoimmune disease.

Not SupportedChronic illnesses are often attributed to genetics or unknown factors in Western medicine rather than environmental or internal triggers.

Not SupportedThe average American eating over 15-16 hours daily is suboptimal and negatively impacts metabolic health and circadian rhythm alignment.

Partially SupportedPharmaceuticals are primarily useful for acute treatment of illness, infection, or traumatic wounds.

Partially SupportedGlycine is used by the body to buffer excess methionine and S-adenosylmethionine (SAMe).

Partially SupportedA study in Denmark showed that increasing fruit and vegetable intake did not significantly change oxidative stress parameters.

Partially SupportedFermented foods may aid in digesting plants better by creating a microbiome more suited to a plant-based diet.

Partially SupportedStable isotope studies suggest humans before the Younger Dryas period consumed a predominantly animal-based diet.

Partially SupportedPeriods of cooling in the last 1,000 to 1,500 years have been correlated with major plagues.

Not SupportedIndividuals with histamine intolerance or FODMAP sensitivities should exercise caution with fermented foods.

Partially SupportedFermentation of vegetables can degrade glucosinolates, potentially reducing plant toxins.

Not SupportedForsaking animal foods risks malnutrition and suboptimal lives due to nutrient deficiency.

Partially SupportedAn optimal meal timing strategy involves kick-starting cortisol and circadian rhythm around 5-7 a.m., fasting for 4-8 hours, starting to eat around 10-12 a.m., eating over 4-8 hours until sunset, and stopping eating at least 4 hours before bed.

Partially SupportedFermentation of plant foods can destroy polyphenols.

Partially SupportedThe central circadian clock in the brain regulates clocks in all organs and cells, governing cycles, metabolic processes, physiology, and behavior.

Not SupportedCalorie restriction is difficult to sustain long-term due to potential feelings of misery, low energy, and nutrient deficiencies.

Partially SupportedObesity, insulin resistance, cardiovascular disease, and hypertension are linked to more severe coronavirus complications.

Partially SupportedSome grass-fed animal protein sources may have lower mineral density due to rainfall, necessitating mineral blocks for cows.

Partially SupportedRamadan fasting improves cardiovascular risk factors and lowers blood pressure.

Partially SupportedExtended daily fasting enables repair and maintenance processes that are absent with continuous food exposure.

Partially SupportedAspects of intuitive fasting can mimic the longevity and healthspan benefits of calorie restriction without severe calorie reduction.

Partially SupportedFasting for 12 hours a day can induce autophagy.

Partially SupportedA 16-hour fast and an 8-hour eating window is a minimum effective dose for fasting's benefits.

Partially SupportedA biphasic sleep schedule, such as a siesta, can be beneficial for lowering stress, improving recovery, and obtaining REM cycles.

Partially SupportedHigh-intensity interval training, meditation, and animal protein are beneficial practices for building character and grit.

Partially SupportedBone meal can be a source of calcium, but caution is needed regarding potential heavy metal contamination depending on the source.

Partially SupportedConstipation can involve methane-producing bacterial overgrowth, mechanical issues, or dysmotility related to insulin resistance, not solely lack of fiber.

Partially SupportedOrgan meats, collagen, and well-sourced mineral salts are valuable supplements for individuals on a carnivore diet.

Not SupportedProton pump inhibitors (PPIs) are associated with increased rates of dementia, pneumonia, and nutrient deficiencies.

Not SupportedSSRIs can cause significant side effects including memory problems, libido issues, weight gain, and lethargy.

Not SupportedConventional medical treatment for eczema and asthma often involves symptom-focused approaches like cortisone cream or inhalers, without exploring potential environmental or neurologic triggers.

Partially SupportedUnderstanding the mechanisms controlling circadian rhythms is crucial for understanding their impact on health.

Partially SupportedWell-raised animal foods and organs likely provide sufficient vitamin C for human optimality from an antioxidant perspective.

Partially SupportedVitamin C intakes around 50-80 mg/day align closely with the RDA and do not appear to impair individuals.

Not SupportedAutophagy can be hijacked by malignant cancers, suggesting it should not be activated constantly and should be balanced with sufficient calories and protein to maintain lean muscle mass.

Partially SupportedThe extinction of megafauna may have been linked to a catastrophic mass extinction event.

Partially SupportedEating one meal a day (OMAD) may offer slightly more autophagy, but the difference is small.

Partially SupportedEating and then immediately sitting is potentially detrimental, especially if the food consumed causes discomfort or spikes insulin significantly.

Not SupportedThe theory that vitamin C competes with glucose for assimilation, thus requiring less vitamin C when glucose is absent, has not been proven.

Partially SupportedSpending more time in a fasted state extends the period of autophagy and energy expenditure compared to spreading calorie intake throughout the day.

Partially SupportedDuring fasting, cells activate pathways that enhance intrinsic defenses against oxidative and metabolic stress and repair damaged molecules.

Partially SupportedTime-restricted eating is an ancestral practice aligned with healthy living principles and can offer health benefits beyond weight loss.

Partially SupportedIntermittent fasting mimics calorie restriction and helps maintain robustness in circadian machinery, including melatonin production and sleep quality.

Partially SupportedNutrient deficiencies, such as boron deficiency, can occur in regions with soil issues.

Partially SupportedThe Icelandic population, known for strength and longevity, eats a very animal-centric diet.

Partially SupportedMany commonly consumed plant foods are defended by the plant.

Partially SupportedREM sleep cycles can be distributed throughout the day and night to meet daily requirements.

Partially SupportedFat is primarily processed during deep sleep in the early part of the night, involving hormones like growth hormone and melatonin.

Partially SupportedExercise and sauna can stimulate autophagy, offering a way to gain autophagy benefits without prolonged fasting.

Partially SupportedThe diet of indigenous peoples studied within the last 100-150 years typically includes few grains, beans, nuts, seeds, and tubers, with a greater emphasis on medicinal plant use.

Partially SupportedCarnivore or animal-based diets may help reverse leaky gut and autoimmune issues.

Partially SupportedSarcopenia is primarily caused by muscle disuse, poor diets lacking sufficient protein and nutrients, and natural decreases in testosterone and growth hormone.

Partially SupportedFermented foods can be a source of vitamin K2 and other nutrients.

Partially SupportedRuminant animal meat is preferred over the meat of monogastric animals.

Partially SupportedA diet focused on animal foods with carefully selected least toxic plants may be beneficial.

Partially SupportedIndigenous hunter-gatherer lifestyles likely supported better soil nutrient quality and overall health.

Partially SupportedFermentation can make foods more palatable and create a calorie source.

Partially SupportedThe nutrient quality of soil is significantly better in ecosystems with natural nutrient cycling compared to monocropping systems.

Partially SupportedDisruptions in circadian rhythms are linked to cardiovascular disease, hormonal imbalances, and sleep disorders.

Partially SupportedNAD is intrinsically connected with circadian rhythms primarily through sirtuins, which regulate genes controlling circadian machinery and energy metabolism.

Partially SupportedNutrient density, particularly from animal-centric diets, is strongly tied to immunological resilience.

Partially SupportedMelatonin regulates circadian rhythm, clock genes, sirtuins, energy metabolism, autophagy, and acts as an antioxidant and sleep hormone.

Partially SupportedSix to 8 hours of sleep is optimal for releasing melatonin, promoting autophagy, and facilitating recovery.

Partially SupportedResolution of clinical or gastrointestinal symptoms can be an indicator of improvement in leaky gut.

Partially SupportedNootropics like caffeine may have a cost associated with their use under high-stress conditions.

Partially SupportedNutritional status and diet nutrient density, rather than genetics alone, may determine infection severity.