Andrew Huberman· PhD
when he fed mice during night time when they're supposed to eat and they're seeing this getting the same number of calories within 12 hours or two hours then the mice left 35 percent longer than they control 35 longer
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when he fed mice during night time when they're supposed to eat and they're seeing this getting the same number of calories within 12 hours or two hours then the mice left 35 percent longer than they control 35 longer
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if you now give Mouse the same caloric restricted diet and fit them during day time whether within 12 hours or two hours then the mice lived 10 percent extra beyond that yes so twenty percent
mice that ate a highly palatable high-fat diet, a great tasting diet, but only during a restricted feeding window of each 24-hour cycle maintained or lost weight over time. Whereas mice that ingested the same diet, same amount of calories, but had access to those calories around the clock gained weight, became obese, and quite sick.
the mice that restricted their feeding window to a particular portion of eight hours of every 24-hour cycle actually showed some improvement in important health markers. And what was even more incredible is that mice that only ate during a particular feeding window also experienced some reversal of some prior negative health effects.
another study compared try machine eating eating with calorie restriction and it turns out in that study that the mice who were eating within like a short eating window like three hours which for them is almost like one meal day and then those mice they had longer lifespans as well as greater health and that they were also protecting against the effects of an obesogenic diet just because of that compared to mice who ate over the course of 13 hours and they were like 5050 with the fasting period and those mice who again ate with no restrictions I beat him around the clock then they didn't saw any of these effects
the group that ate ad libitum or like around the clock and that that those mice were significantly heavier and they were basically sand they developed medivac syndrome and insulin resistance just because they were in this constantly fayette state and they didn't allow the body to go through like period of off of a longer fasting period and compared to the other mice who ate the same and the same in the same amount of calories but they were not the beasts and they're kind of protected against the against it
Yes, we did see lean muscle mass improvement only on mice that were given standard diet, not on high fat diet. Okay. The high fat diet fed mice... Yeah, I wouldn't expect for them. So they were given...so the mice that were given the normal, sort of healthier diet. Yeah. What was their eating schedule? They were eight to nine hours. So it was a shorter time window they were eating? Yeah, yeah yeah. They had increased lean muscle mass.
And we realized that their grip strength, which is similar to how much weight a person can lift, that did not change, that stayed the same. But the endurance, being on the treadmill for a long time, that actually significantly increased, and in some cases it doubles.