Paul Saladino· MD
there is this connection between the methionine and glycine balance if you get too much methionine without enough glycine it's going to mess up your biochemistry
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there is this connection between the methionine and glycine balance if you get too much methionine without enough glycine it's going to mess up your biochemistry
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I think that the key with collagen is the Matheny and glycine ratio absolutely
if you over feed rodents Metheny which is a sulfur amino acid that's relatively higher in muscle then connected tissue those rodents live a shorter amount of time yeah and so that is a piece of evidence that gets often repeated and very rarely understood they were doing the finding over feeding and yes all the animals have a problem and I think it's pretty clear based on human biochemistry that if we over feed Metheny yes we're going to have stress but it's not the total amount it's the ratio exactly
and that's when they supplemented their outsides with glycine they had Life Extension
it's that's really the issue here that it's that's the methionine glycine balance that we need to think about rather than the amount of Matheny and
he refers to mouse studies and rodent studies where they overfed the mice with methionine and what they saw when they overfed the mice with my thiamine was they did get a shortening of a lifespan of the mouse well what you dig into there is this biochemistry around the Metheny and glycine balance and the idea that subsequently when they restricted them a thiamine in the mouse's diet they got the mouse live longer they said ah see here's the thing protein ages us Matheny and ages us and I think this is his argument that animal protein is higher in methionine then plant protein
what was really going on there was that by over feeding the animals in the finding they were in balancing the Matheny and glycine ratio and when they gave the animals a robust amount of methionine and just gave them glycine at the same time the glycine extended the lifespan of the mice so it was it was the Matheny and glycine ratio
there were a series of experiments in the 60s and 70s done with mice that are often cited by proponents of plant-based diets for people who are against the animal-based diets saying that methionine restriction was beneficial for longevity or that methionine overfeeding was damaging for rats but what they don't talk about is that when you add enough glycine to balance the methionine you see longevity effects