David Sinclair· PhD
In mice, Rafa de Cabo and team @NIH show @Cell_Metabolism that a long daily period of fasting improves survival, regardless of food intake, diet, and body weight.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
In mice, Rafa de Cabo and team @NIH show @Cell_Metabolism that a long daily period of fasting improves survival, regardless of food intake, diet, and body weight.
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the one of the researchers of the study concluded that increasing daily fasting times without a reduction of calories and regardless of the type of diet consumed resulted in overall improvements in health and survival and male mice perhaps this extended daily fasting enables repair and maintenance that would be absent in continuous exposure to food
Time-restricted eating and longer daily fasting times improved health and longevity independent of calories or diet composition in male mice.
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.