Curcumin has potential side effects, including affecting the p53 tumor suppressor gene, thyroid oxido-reductase, topoisomerase 3, and potassium channels.

“accumulating data have demonstrated since then that curcumin can induce DNA damage chromosomal alterations in both in vitro and in vivo concentrations similar to those reported to exert beneficial effect for instance curcumin concentrations of 2.5 and 5 microgram per ml were shown to induce DNA damage to both mitochondria and nuclear genomes and cells these reports raise concern about curcumin safety as the induction of DNA alterations is a common event in carcinogenesis”

“curcumin many side effects potentially affecting the p53 which is a major tumor suppressor gene affecting thyroid ox and reductase affecting topoisomerase 3 affecting the her channel which is a potassium channel”

“in the case of curcumin it's known to inhibit topoisomerase enzymes which wind and unwind dna it can affect p53 which is a tumor suppressor gene in the negative fashion it affects the herd channel which is a potassium channel”