Paul Saladino· MD
probably because excess vitamin C in the human body leads to oxalate and then when we excrete oxalate in the kidneys depending how well we're excreting oxalate I can form calcium oxalate kidney stones
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We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
probably because excess vitamin C in the human body leads to oxalate and then when we excrete oxalate in the kidneys depending how well we're excreting oxalate I can form calcium oxalate kidney stones
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there is a risk that that vitamin C can become itself oxidized one of the oxidized forms of vitamin C is oxalate boys or girls oxalate and then that can become precipitated out with with calcium mainly calcium but in fact any of the metallic ions and course crystals and cause damage and cause inflammation and cause stones and causes all sorts of havoc all around your body
when we take excess vitamin C we are harming ourselves that we are creating excess oxalates we are oxidizing b12 we are giving ourselves GI distress force potentially disrupting the GI membranes I know the Paleo medicine group has argued the vitamin C may actually cause leaky gut in high amounts
potentially more especially in the form of supplements might even be dangerous we know that vitamin C can turn it to oxalate anyone who's listening this podcast probably knows all about oxalate and how we maybe don't want a whole bunch of that anyway
so I'm not convinced we need mega doses of vitamin C Chris Master John and I disagree with on this as well but I'm just not convinced there's really good evidence that anything above maybe 30 to 70 milligrams a day which is easily obtainable from animal foods it's optimal for a human as James and I talked about potentially more especially in the form of supplements might even be dangerous we know that vitamin C can turn it to oxalate anyone who's listening this podcast probably knows all about oxalate and how we maybe don't want a whole bunch of that anyway
excess vitamin C I think may have harmful effects in humans and there's some suggestion that it can lead to increase incidence of kidney stones which shouldn't be surprising for us because asked Orbach acid can be broken down into oxalic acid and that has to be excreted so our mega doses of vitamin C about 500 milligrams potentially harmful I think they might be
but the um certain amino acids hydroxyproline proline glycine they're kind of starting to downplay in some studies i there's still a lot of confusion around this this is difficult stuff to study and i don't think it's been a huge priority but you need vitamin c vitamin c v6 to get the proper conversion back and forth between glycine and if you get if you don't have enough b6 or b1 some otherwise innocent molecules can more and more become this um precursor to oxalate what is it glycoglycoxylate like glyoxylate yeah and so you get a buildup of glyoxylate and then you're going to have more of that becoming oxalate in the body
A small number of case reports indicate that a condition called oxalate nephropathy in which oxalate calcium crystals form in the kidney has been observed when patients with kidney impairment were given high doses of intravenous vitamin C