Paul Saladino· MD
when we look at my hormones especially my testosterone and my sex hormone binding globulin i will again reference the importance of having some insulin spikes for sex hormone binding globulin
Loading…
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
when we look at my hormones especially my testosterone and my sex hormone binding globulin i will again reference the importance of having some insulin spikes for sex hormone binding globulin
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
we know that insulin has beneficial actions by lowering shbg as i mentioned at the beginning of the podcast my section one binding globulin remains slightly above the reference range but about half of what it has been in the past which results in much higher levels of free androgens which are good for all sorts of things muscle mass libido all kinds of things beneficial there
we know that we need insulin at some level to keep sex hormone binding globulin down so we have free hormones especially testosterone for men
as insulin comes down shbg tends to go up as T4 goes up shbg goes up and as estrad goes up shbg goes up
all things equal, when insulin goes down, which is usually what happens when you restrict carbohydrates, sex hormone-binding globulin goes up. That means if you have no change in testosterone level or even estradiol level, free testosterone will go down.
That means if you have no change in testosterone level or even estradiol level, free testosterone will go down. Less testosterone is around to be unbound to the sex hormone-binding globulin.
So, the SHPG levels will be dictated by age, will be dictated by liver health to some extent, will be dictated by other medications, especially oral formulations. Um, insulenic signaling as well hugely implicated.
but in general is going to be the insulinogenic signaling is somewhat necessary to facilitate a balance of free androgens, including free other hormones in the body that often go overlooked to actually do what they're supposed to do.
But in reality, they had like borderline hypoganatal free test levels often because they were overlooking the fact that insulenic signaling is needed to actually get SHBG to a meaningfully reasonable level for a male.