Audit a URL →

Sign in Sign up free

Loading…

Weekly · Sunday Morning

Five longevity claims.
Worth your time.
Every Sunday.

Last Sunday

Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

5 audits·1 verdict change·0 affiliate links·Every Sunday

Joining 1,247 readers — founders, MDs, and longevity-obsessed people who fact-check their own health decisions.

Browse

Decisions Claims Content Creators

Product

Audit a URL Sunday roundup API (soon)Pricing

About

FAQ Methodology Editorial Standards Corrections Press & brand RSS feed

Legal

Terms of Service Privacy Policy DMCA

Finally, something serious in this space.
Because we actually read the papers.

© 2026 Whalespan. Independent, evidence-graded longevity.

Diabetes & insulin resistance — Whalespan

Content›Video›Diabetes & insulin resistanc…

Diabetes & insulin resistance

Paul Saladino10m · 2022-10-21

Claims Made

25

Claims Supported

23

Support Rate

92%

Support rate

23 of 25 claims supported

23 supported2 partial / not

Claims from this content

16

✓Well SupportedBreakdown products of linoleic acid, such as 4-HNE and 13-HODE, are associated with pathological fat cell phenotypes and insulin resistance.✓Well SupportedLinoleic acid content varies significantly across foods, with seed oils containing 20-55% and tallow/butter containing 1-2%.✓Well SupportedBroken fat cells cause insulin resistance, and fixing them may lead to weight gain if dietary habits remain unchanged.✓Well SupportedPaul Saladino remains insulin sensitive despite significant carbohydrate consumption due to his blood work foundation and not being obese or diabetic.Well Supported

Discussion

Native comments, Twitter mentions, and Reddit threads about this content — surfaced together so the conversation isn't fragmented across platforms.

M

Share your read of this content…

Posting publicly as you · linked to your social profiles

Sort by:

AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓

A fasting insulin level of 8.6 micro IU/mL is likely too high for most people, contributing to the high prevalence of metabolic syndrome.

✓Well SupportedIncreased and evolutionarily inconsistent consumption of linoleic acid causes metabolic dysfunction, insulin resistance, and related chronic diseases.

✓Well SupportedFasting insulin levels should be used to diagnose diabetes, as current reference ranges are too high.

✓Well SupportedWhen fat cells become hypertrophic, they release inflammatory mediators and experience macrophage infiltration, which is associated with insulin resistance and vascular endothelial dysfunction.

✓Well SupportedPhysiological insulin resistance is a normal and protective state in a ketogenic state.

◐Partially SupportedHigh free fatty acids and high insulin can occur in pathological states like sickness, injury, or inflammation, inducing insulin resistance.

◐Partially SupportedAnimal fats like tallow, ghee, and butter are preferred over high-linoleic acid oils due to their low linoleic acid content.

◐Partially SupportedAn animal-based diet high in saturated fat and carbohydrates exceeding 200 grams per day resulted in fasting insulin levels below 3 micro IU/mL.

✓Well SupportedElevated circulating free fatty acids can inhibit muscle glycogen synthesis by interfering with insulin signaling in individuals predisposed to diabetes.

✕Not SupportedThe Western medical approach to diagnosing and treating insulin resistance and diabetes is flawed, relying on metrics like A1c and failing to consider comprehensive dietary changes.

◐Partially SupportedFat cells in diabetic physiology have broken hyperplasia, meaning they cannot divide and can only expand (hypertrophy).

✕Not SupportedA pre-diabetic woman with a high grain intake and frequent oil use may have high fasting insulin and be inappropriately prescribed metformin.