Paul Saladino· MD
but that receptor is also important for mood and proper mental health
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
but that receptor is also important for mood and proper mental health
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then they do it in humans and they find that it increases the rates of suicidality and depression
it also makes people suicidal but it actually can affect satiety in a positive way meaning increasing satiety by giving people ramona van it's an incredibly effective weight loss drug but it turns out blocking the cb1 receptor i believe is what it is is great for satiety
blocking a cannabinoid receptor in humans do it creates less hunger it blocks our impulse at hunger and people lose weight
it's an inverse agonist of the cb1 receptor in humans meaning that it's essentially at the end of the day going to block the cannabinoid one receptor in humans now what does blocking a cannabinoid receptor in humans do it creates less hunger it blocks our impulse at hunger and people lose weight
Rimonabant was a drug approved in the early 2000s for use as an anti-obesity, as a weight loss drug. Rimonabant is a CB1, a cannabinoid 1 inverse agonist, meaning that it blocks the cannabinoid 1 receptor by activating it incorrectly. So, what you have with rimonabant is something that is the opposite of 2-AG and anandamide, and it did lead to satiety, less feelings of hunger, and weight loss as you can see in these trials.
if you block cannaboid receptors people become less hungry if you activate cannaboid receptors they become more hungry