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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
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What is cholesterol? — Whalespan

Content›Video›What is cholesterol?…

What is cholesterol?

Paul Saladino13m · 2022-06-22

Claims Made

17

Claims Supported

13

Support Rate

76%

Support rate

13 of 17 claims supported

13 supported4 partial / not

Claims from this content

15

✓Well SupportedInsulin resistance makes LDL 'stickier,' increasing cardiac risk, while individuals who are insulin sensitive show no increase in cardiac risk with higher LDL levels.✓Well SupportedIncreasing saturated fat and decreasing polyunsaturated fat intake is associated with lower plasma concentrations of lipoprotein(a) and oxLDL-EO6.✓Well SupportedApolipoprotein B (ApoB) is the primary marker for atherogenic particles, while Apolipoprotein A (ApoA) is associated with HDL.✓Well SupportedSaturated fat might be a normal adaptive response to maintain cell membrane fluidity, even if it raises LDL cholesterol.Well Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓

Cholesterol is essential for cell membrane structure and is a substrate for vital hormone production.

✓Well SupportedIncreased overall saturated fat intake generally leads to higher LDL levels, although some saturated fats like stearic acid may not.

✓Well SupportedElevated LDL cholesterol with large, buoyant lipid particles is not indicative of a problem in the context of high insulin sensitivity.

◐Partially SupportedLower fasting insulin levels are associated with higher free fatty acid levels, suggesting the body is mobilizing free fatty acids.

◐Partially SupportedHigher HDL levels are more prevalent than LDL, and HDL does not cause atherosclerosis.

◐Partially SupportedCholesterol is essential for maintaining cell membrane fluidity.

◐Partially SupportedLipoproteins, including LDL, are essential for life and transport cholesterol needed for cell membranes.

◐Partially SupportedApolipoprotein B is critical for LDL particles to be taken into the cell membrane, initiating atheroma formation.

◐Partially SupportedCholesterol esters and triglycerides are transported in the bloodstream via lipoprotein particles, analogous to a bus system.

?Limited ResearchThe role of LDL in cardiovascular plaque formation is debated.

✕Not SupportedThe classification of lipoproteins as 'bad' (non-HDL) is questioned, as they are essential for life.