Saturated fat might be a normal adaptive response to maintain cell membrane fluidity, even if it raises LDL cholesterol.

“the more saturated fat you eat and the less monounsaturated and polyunsaturated fat you eat the more your LDL goes up is basically what people see”

“there's something called the homeo viscous model of membranes that's been promulgated recently whereby people suggest that when you're eating more saturated fat that your body has to increase the ldl to carry more of the cholesterol molecule to make the membranes have a standard level of viscosity fluidity in the membrane”

“an sfa a saturated fat induced rays in ldl cholesterol and healthy individuals could represent a normal rather than a pathological response and that is because as the membrane becomes more enriched with saturated fat you must put more cholesterol into the membrane to maintain its fluidity”

“we talked about a hypothesis called the homeobiscus model for why your cholesterol quote unquote more specifically your ldl may rise when you eat more saturated fat your body must put more cholesterol into the membranes so your ldl rises because your body is delivering more cholesterol to the membranes that sounds adaptive rather than pathological to me”

“the homeobiscus adaptation to dietary lipids h-a-d-l model which explains changes in lipoprotein cholesterol as adaptive homeostatic adjustments that serve to maintain cell membrane fluidity and helps hunt optimal cell function due to the highly variable intake of fatty acids and humans and other omnivore species we propose that circulating lipoproteins serve as a buffer to enable the rapid redistribution of cholesterol molecules between specific cells and tissues that is necessary with changes in dietary fat supply”

“so they'll say here in this paper we propose in this paper we propose a novel model the homeobiscus adaptation to dietary lipids h-a-d-l model which explains changes in lipoprotein cholesterol as adaptive homeostatic adjustments that serve to maintain cell membrane fluidity”

“the idea that your body wants to keep the cell membranes at a regulated constant level of fluidity and that when you have more saturated fat in those membranes the body may need to make more cholesterol the level of the liver and Export that cholesterol in LDL particles to the membranes to keep them fluid”

“conversely having more saturated fat in your diet means more saturated fats in your membranes and remember that saturated fats are going to populate phospholipids with two straight tails while a polyunsaturated fat will populate a phospholipid with a king tail which makes the membrane more fluid in a saturated fat Rich diet according to the homeopiscus model there's probably going to be more cholesterol in the blood because of the body's intention to keep the membrane at the same level of fluidity so that your cells are not too stiff and they're not too jelly and they don't fall apart so there are many physiologic reasons that are not pathological by which eating more saturated fat and less polyunsaturated fat May raise your LDL”

“saturated fat on clearance was altering membrane permeability and the LDL receptor was there for losing efficacy yeah right that's right I think we're current understanding of why saturated fats raise cholesterol raise LDL now”