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Why does LDL rise on an animal based diet? — Whalespan

Content›Video›Why does LDL rise on an anim…

Why does LDL rise on an animal based diet?

Paul Saladino8m · 2022-05-18

Claims Made

22

Claims Supported

12

Support Rate

55%

Support rate

12 of 22 claims supported

12 supported10 partial / not

Claims from this content

21

✓Well SupportedSaturated fat might be a normal adaptive response to maintain cell membrane fluidity, even if it raises LDL cholesterol.✓Well SupportedFasting can increase serum LDL, potentially indicating LDL's role in substance transport.✓Well SupportedIncreasing saturated fat and decreasing monounsaturated and polyunsaturated fats in the diet leads to higher LDL cholesterol for approximately 70% of people.◐Partially SupportedWhen ldl increases, particle size typically increases, and particle number may not be as critical as metabolic health.Well Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓

Elevated triglycerides, fasting insulin, and overall insulin resistance are better indicators of cardiovascular risk than NMR profile metrics.

✓Well SupportedSubstituting monounsaturated fats for saturated fats may be preferable for preventing atherosclerosis compared to substituting polyunsaturated fats.

◐Partially SupportedThe speaker's LDL particles measure approximately 24.7 nanometers, near the upper limit of the reference range.

✓Well SupportedA fasting insulin measurement could significantly change the landscape of chronic disease if doctors were trained to interpret and act upon it.

◐Partially SupportedIncreased monounsaturated or polyunsaturated fat intake can make cell membranes more fluid, prompting the body to lower cholesterol levels.

◐Partially SupportedThe speaker's lipid panel shows an LDL of approximately 220 mg/dL, triglycerides of 70 mg/dL, and HDL of 85 mg/dL.

◐Partially SupportedIt is evolutionarily consistent for humans to consume saturated fats and lower amounts of monounsaturated and polyunsaturated fats.

✕Not SupportedWestern medicine's assessment of cardiac risk is myopic by focusing only on LDL/ApoB and ignoring triglycerides, HDL ratio, fasting insulin, and fasting glucose.

✕Not SupportedThe assumption that higher LDL levels directly cause more atherosclerosis may be incorrect.

?Limited ResearchAPOB-containing particles may not be directly injurious to the endothelium and sufficient on their own to cause atherosclerosis.

◐Partially SupportedLDL cholesterol levels can increase due to higher saturated fat intake or the presence of ketones.

◐Partially SupportedIn lean mass hyper-responder phenotype, triglycerides decrease, HDL cholesterol increases, and fasting insulin decreases.

◐Partially SupportedMost studied hunter-gatherer populations have LDL levels around 100 mg/dL and do not exhibit lean mass hyper-responsiveness.

◐Partially SupportedThe lean mass hyper-responder phenotype is characterized by low triglycerides, high HDL, and elevated LDL.

✕Not SupportedExcessive intake of polyunsaturated fats, particularly from seed oils, lowers LDL cholesterol in a non-beneficial way.

◐Partially SupportedIf high LDL levels in lean mass hyper-responders do not correlate with increased atherosclerosis, it would challenge the role of LDL and apob as primary drivers of cardiovascular disease.

◐Partially SupportedA study by Dave Feldman is investigating whether lean mass hyper-responders with high LDL levels develop more atherosclerosis over time via CT coronary angiography.