When ldl increases, particle size typically increases, and particle number may not be as critical as metabolic health.

“my only Oh particles were very large they were twenty two point four nanometers and I jokingly asked Spencer whose balls were bigger you know like whose particles were bigger he didn't measure microns there come on you know her the LDL size not the kind of micron but yeah yes heating it back to me but again I Spencer is a great guy and we're gonna probably more gonna be working together like advance the understanding of lipids but the thing is that uh and I live in the setting of an elevated LDL”

“what's the size of an HDL particle relative the size of an LDL particle it's considerably smaller and considerably more dense”

“as your LDL goes up the particle number goes up concordant and when the particle number goes up your small dense particles will also be a little high but overall size of your LDL molecule would be very large”

“when ldl goes up if the particle size doesn't is what increases not the particle number usually and people want to say oh particle number is imported i'm actually not convinced the particle number matters that much”

“it's gonna say that i have small ldl that's high and medium ldl that's high but again this is just because i have a large number of ldl particles and every distribution every human has a semi-gaussian which is a bell curve distribution of ldl particles some are going to be small some are going to be medium it's going to be large”

“So that spectrum of particles, we started to break down with methodology that I was fortunate enough to have available to me and helped develop to show that these different forms of LDL across this spectrum really have very different metabolic and pathologic properties.”