Andrew Huberman· PhD
There are two broad families of lipoproteins. There are those that are wrapped in ApoBs, and those that are wrapped in ApoAs. The ApoA family is the HDL family. The ApoB family is the VLDL, IDL, LDL family.
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
There are two broad families of lipoproteins. There are those that are wrapped in ApoBs, and those that are wrapped in ApoAs. The ApoA family is the HDL family. The ApoB family is the VLDL, IDL, LDL family.
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ApoA1 is the April lipoprotein that identifies HDL particles bein in a general sense yeah yeah an April B would can be either April be 48 on chylomicrons or April be 100 on LDL LDL particles
apob which is essentially synonymous with ldl if you guys have heard of april b able b is an abella protein that's on the ldl surface
you can also get other uh april if a protein b containing particles like chylomicrons and like ldl i'll show you lipoprotein metabolism in one moment this is another representation here you can see ldl just has b100 idl able to protein e nb 100 vldl v100 a lipoprotein e and a lipoprotein c2 so kylo microns b48 able for protein c2 a1 able to protein e and hdl is over here we'll get it to that eventually able to protein a1 e and c2
the VLDL the IDL and the LDL all have the a PO be 100 the HDL does not the HDL has something called a PO a one it's a different lipoprotein and it probably explains in large part why HDL is not atherogenic and LDL is atherogenic
there's one protein they never lose and it's the one that has the most mass of molecular weight April hyper protein B so that's why they are never gonna be as dense as an HDL particle cousin H cos doesn't have this monstrosity high molecular weight April B on it
he talked about hey April be 100 April be 48th April be is a giant structural non-transferable April protein that's on chylomicrons or vldls
April B is just a way for the labs to report to you what an LDL particle concentration is
within every class of lipoproteins you're gonna have a heterogeneous range of densities from big species to small species and this is why to me I like to tease because you always hear people talk about the small dense LDL within every lipoprotein classification the smaller particle is always more dense then
by measuring the concentration of apob you can completely and accurately measure the concentration of the atherogenic particles the majority of which are ldl and the reason for that is twofold the first is that every ldl has one and only one apob 100 particle on it the second is that all apob's are the same size therefore they have a molar weight and by knowing the mass you know the number
HDL which we're going to be talking about today is also a lipoprotein it's a very complex lipoprotein it doesn't have this key Protein apob that's what differentiates them that's why we often refer to the APO B containing lipoproteins and then HDL is the other half as you said and HDL really is characterized by a different protein called apoa1