Paul Saladino· MD
it's very clear I don't think anyone can make a position that non oxidized LDL or native LDL could be damaging to our arteries
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
it's very clear I don't think anyone can make a position that non oxidized LDL or native LDL could be damaging to our arteries
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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i think it's widely accepted that native ldl does not initiate atherosclerosis that native ldl will not get taken up by the macrophage in the sub-endothelial space
native ldl non-oxidized ldl doesn't get retained in the sub-interval space
the takeaway here is that macrophages only engulf LDL when it's oxidized it's not when it's native
brown and Goldstein many years ago clearly showed that macrophages don't take up native LDL in the sub-endothelial space they only take up oxidized LDL
the “squeeze into the sub-endothelial space”. This is what triggers the inflammatory response.