The primary targets for cardiovascular health should be insulin resistance and the subsequent susceptibility of LDL to oxidation, rather than LDL-C itself.

“it's the insulin resistance that is the atherogenic component rather than the LDL itself”

“in people who are insulin resistant if you have more LDO you may have more fuel for the fire but it's the insulin resistance that provide that is the total overarching context and I believe it's the insulin resistance that is the spark that burns the wood”

“the real targets are probably in my opinion insulin resistance first and foremost and then the subsequent increase in the susceptibility of LDL for oxidation and the connected increased cardiovascular risk with LP little a and those are very different targets than ldlc per se”

“I think that we should be focusing on LP little a which is a much better risk factor oxidized LDL in the RT material wall and most importantly insulin sensitivity”

“the real targets are probably in my opinion insulin resistance first and foremost and then the subsequent increase in the susceptibility of LDL for oxidation and the connected increased cardiovascular risk with LP level a and those are very different targets than ldlc per se”