Paul Saladino· MD
LDL has so many incredible roles cellular membrane components how can we malign this molecule so much we should be celebrating this molecule it's an incredibly valuable thing to have in our bodies
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
LDL has so many incredible roles cellular membrane components how can we malign this molecule so much we should be celebrating this molecule it's an incredibly valuable thing to have in our bodies
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LDL has all of these valuable functions in the human body LDL is an amino logic mediator we know that it affects quorum sensing by by bacteria when bacteria invade our body they put all these molecules to communicate to other bacteria saying hey it's okay come in and invade an LDL mops those up LDL can also be involved directly in the immunologic response LDL carries cholesterol to the testes and the ovaries these are tissues that potentially don't make their own cholesterol and so it's invaluable that that cholesterol backbone gets delivered so we can make sex hormones and be healthy individuals LDL also carries molecules that are involved in energy production among other roles
second thing ldl has critical immune functions in the human body which i'll show you guys a little later it interrupts quorum sensing which is the communication between bacteria and we know in both animal and human experiments that if you decrease the ldl animals get more sick and in humans who have lower levels of ldl they have increased rates of communicable infectious disease so ldl is an immune particle