Paul Saladino· MD
the oxidized phospholipids apob tertiles and lppla2 tertiles clearly determine how bad lp little a levels are
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
the oxidized phospholipids apob tertiles and lppla2 tertiles clearly determine how bad lp little a levels are
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all of these markers are going to go up even most conventional assays of oxidized ldl go up because they are boolean they're a monoclonal antibody to oxidize phospholipids so they can only tell you with a yes or no answer if an ox if they can only tell you with a yes or no answer if an ldl particle contains an oxidized phospholipid they don't tell you what the percentage of oxidized phospholipids on ldl is
And then, if you can assess either the oxidized LDL or preferably the oxidized phospholipid on apoB, if that's elevated, then it's kind of like fire and dynamite. You think that LPA is probably pretty metabolically active at that point. So, those are the people I can put in the super high-risk bucket.
there's another thing called it's the oxidized phospholipids over the a bow B and in that paper it's a 2007 paper and I think some Mekas is the last author on it as well all over the place they show the hazard ratios and it's a J curve so that the very the lowest they caught the sextile so they have they partition it into six different groups on the lowest if you look at the hazard ratio the hazard ratio is about two
the ox LDL assay is different from the ox PL assay the ox LDL assay works independent of how many 8bo ways you have okay
if you say well these oxidized phospholipids are on all the apob particles to a minuscule degree for because of the affinity of oxidized lipid mortise to apoa the overwhelm if you have a positive oxidized phospholipid april b the overwhelming majority of apob particles trafficking those oxidized lipids are lp little a particles
if two people came to consult me tomorrow they both have an elevated lp little a metric one has a normal oxidized phospholipids on april b but the other one is elevated based on samsumicus and others worse work i'm going to be a little more worried about that person who's my god not only do they have this undesirable particle but this particle is loaded down with injurious other lipids that are potentially very harmful
we are beginning to have metrics that are starting to appear and available in the real world that we can measure the oxidation the oxidized lipid moieties that are on april little a they're actually it's called oxidized pl fossil lipids on april b
but the i think the most important thing is the number of oxidized phospholipids that are transported by lipoprotein literally which is much higher than the amount of oxidized phospholipids that that you see on ldl particles
but the the i think the most important thing is the number of oxidized phospholipids that are transported by lipoprotein literally which is much higher than the amount of oxidized phospholipids that that you see on ldl particles