We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
the difference between 1,600 times 10 to the 14th and 900 times 10 to the 14th is essentially zero right it's not even an order of magnitude people need to see how big these two numbers are right to say that that is the that is the basis of atherosclerosis is a concentration gradient yeah I mean it's it's a it's absurd
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so to say that that's what's going on is absurd to me it doesn't really make sense like yes someone can have a smaller number of particles but think about it in the grand scheme of things like that the scale is just enormous
you've got someone with a massive atheroma right in their artery here and it's just about to burst it's enormous it's catastrophic just down a millimeter away or even across the wall the endothelium and the artery is in perfect health with no issue that person at the same LDL particle count why is atherosclerosis massively focal it's in specific spots you've got the same particle
I don't believe that this this LDL phenomenon is the best metric of atherosclerosis a it's because the system is super saturated because just because there's there's so many particles even at 900 animal per liter you know like that there are there the system is saturated you are still getting a ton of particles moving in and out you just can't convince me that 1600 and 900 is the difference it just doesn't make sense to me
the arguments around LDL particle number would suggest that okay the more LDL you have in your circulation the more of it is going to get into the end of the seventh ileal space just by a rule of osmosis just a concentration gradient but one of the things that speaking with people in the space has really pointed out to me is that that's a really absurd thing to say because when you actually look at the numbers what I was saying before holds true think about my olio particle number 1,600 times 10 to the 14th particles of LDL and you're the difference between if I had a if I had a an LDL particle number of a thousand or 900 people would say oh you don't have any you're not at risk the difference between 1,600 times 10
and so if LDL were truly atherogenic in and of itself if LDL were truly toxic to the
if you do the numbers ldl is massive no matter whether you're 70 milligrams per deciliter or 250 milligrams per deciliter we're talking 10 to the 15th ldl particles either way