Paul Saladino· MD
ApoB containing lipoproteins being involved with the atherosclerotic process doesn't mean they CAUSE this process. This is a very important distinction.
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We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
ApoB containing lipoproteins being involved with the atherosclerotic process doesn't mean they CAUSE this process. This is a very important distinction.
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The process of atherosclerosis does NOT begin with ApoB, it begins with damage to the endothelium lining blood vessels...
my concern personally and I believe that you may share this concern is that within the medical community this type of evidence is being conflated with the notion that because apob lipoprotein containing lipoproteins are clearly involved in the progression many believe that they are causal and to me that would mean a clear proof of direct endothelial which is the lining of blood vessels a direct endothelial damage of LDL
and to me and I believe to you that is an equation that is incomplete
i think there's enough evidence to say i don't think we can prove that apob containing particles which is mostly ldl but isil includes things like chylomicrons etc are directly injurious to the endothelium
because we've come to believe that apob containing particles specifically vldl ldl chylomicrons are the causative agents of atherosclerosis i think this is completely wrong and i will question that now
this is the damage to the endothelium that is the inciting factor that is the proximate event that is the first step in atherosclerosis I I and I really think this is important to emphasize because many in the health space would argue that APO b or LDL is the first step in atherosclerosis and that doesn't make any sense to me and I think if you look at the data it's absolutely not supported to say that LDL is the first step in atherosclerosis