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Weekly · Sunday Morning

Five longevity claims.
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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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LDL is not causing heart disease — Whalespan

Content›Video›LDL is not causing heart dis…

LDL is not causing heart disease

Paul Saladino9m · 2022-09-02

Claims Made

20

Claims Supported

6

Support Rate

30%

Support rate

6 of 20 claims supported

6 supported14 partial / not

Claims from this content

16

✓Well SupportedMetabolic dysfunction, specifically insulin resistance, is the primary event leading to atherosclerosis, not LDL directly injuring the endothelium.✓Well SupportedWhen Framingham data is not stratified by metrics associated with insulin resistance, LDL cholesterol shows a linear correlation with cardiovascular disease incidence.◐Partially SupportedLDL is not problematic unless an individual is insulin resistant and is involved in arterial healing.✕Not SupportedAtherosclerosis begins with damage to the endothelium lining blood vessels.Not Supported

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✕

There is insufficient solid data directly indicting LDL and apob-containing particles as the cause of endothelial injury leading to atherosclerosis.

◐Partially SupportedLowering LDL in individuals with diabetes and damaged endothelium is reasonable, but correcting the root cause of diabetes is also crucial.

◐Partially SupportedMany individuals on ketogenic or carnivore diets experience elevated LDL cholesterol, which can cause concern when doctors recommend statins.

◐Partially SupportedA study is comparing atherosclerosis progression via CTAs over one year in a regular cohort and a lean mass hyper-responder cohort.

✕Not SupportedAPOB-containing lipoproteins are not causative of atherosclerosis, although they may be involved.

◐Partially SupportedIf LDL causes atherosclerosis, then LDL should be lowered to the lowest possible level in all humans.

✕Not SupportedIndividuals with glycogen storage disease 1a, who have elevated LDL but no increased atherosclerosis, challenge the idea that LDL is causative of atherosclerosis.

✕Not SupportedMany physicians focus on LDL and apob as direct causes of atherosclerosis, rather than underlying issues.

◐Partially SupportedIn individuals with diabetes and damaged endothelium, higher LDL levels are likely worse.

✕Not SupportedIf fasting insulin is low, LDL is not considered causative of atherosclerosis; it is seen as a response to inflammation.

✕Not SupportedDunnigan familial lipodystrophy is characterized by normal LDL levels but severe atherosclerosis, contradicting the LDL causation hypothesis.

◐Partially SupportedAtherosclerosis does not form in veins unless they are grafted into the arterial circulation.