The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
the hazard ratio of all cause mortality associated with compromised kidney function is even greater than that of heart disease once once you cross that threshold I mean lights out once you are needing dialysis I mean your risk of death is higher than that of someone with high blood pressure smoking even someone who has cancer you have a higher risk of death having endstage renal disease than you do having cancer
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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To give you a sense of scale, having end-stage renal disease (ESRD) carries a hazard ratio of 2.78 for ACM (a 178% increase), which is even greater than the ACM hazard for smoking, type 2 diabetes, and coronary artery disease.