Paul Saladino· MD
there are populations around the world who have higher particle numbers on average than Americans and those populations have almost no heart disease
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
there are populations around the world who have higher particle numbers on average than Americans and those populations have almost no heart disease
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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the problem is that sometimes they don't correlate with that as you've pointed out you know there are populations in the world for who the LDL particle number is higher and you actually don't see an increase in cardiovascular disease