Peter Attia· MD
that can occur directly which is when the HDL brings cholesterol itself back from another tissue to the liver and the most important place it does this is from the sub endothelial space
Loading…
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
that can occur directly which is when the HDL brings cholesterol itself back from another tissue to the liver and the most important place it does this is from the sub endothelial space
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
they are primarily responsible for reverse cholesterol transport of which there are two types reverse cholesterol transport means taking cholesterol from the periphery back to the liver
reverse cholesterol transport means taking cholesterol from the periphery back to the liver that can occur directly which is when the HDL brings cholesterol itself back from another tissue to the liver and the most important place it does this is from the sub endothelial space so if you have oxidized sterols waiting to cause atherosclerosis the HDL can actually go and through another one of those atp-binding cassette sit candy lipid ate the HDL the sterile take it right back to the liver that's direct RCT but there's also indirect RCT which is the LDL can bring cholesterol back and give cholesterol to the HDL through C temp as you alluded to and that goes the other way right like you mean HDL actually taking the cholesterol and giving it to the LDL to take back to the liver no the well actually both so LDL gives to HDL to go back to the liver I see yeah through Seto so that's indirect RCT but it's that VLDL to IDL to LDL path that is governed by these a poby like their lineage is described by a PO b100 which differentiates them
raising an HDL metric in a clinical trial maybe if you want to do an HDL metric hits HDL particle count
saying oh it's a this lipid transportation system is way more complex than an HDL bringing it back and it knows we give it a different name now
when we really talk about the positive valence of HDL as a particle it's because of this right in large part this is a big piece of the positive Association presumably or negative association depending on the direction of hdlc we might see as we've been talking about it
these large hdls take apple e on board and as you know Apple e is also a ligand for the LDL receptor so the large HDL particles are also cleared by the liver
you can take the HDL particle and you can break it down into a range of sizes with a larger the size of HTO article being a healthier type and what that the larger particle of HDL reflects a very important function of htl and that is this thing called reverse cholesterol transport so when reverse cholesterol transport is occurring that is when the HDL particle is taking cholesterol back from the periphery to the liver which is a healthy function
you know hd's age these big HDL particles are taking cholesterol from the periphery meaning even cholesterol plaques that have been on that are on the artery and removing them and bringing them to the liver
But then you can take the HDL particle and you can break it down into uh a range of sizes with a larger size of HDL particle being a healthier type. And what that the larger particle of HDL reflects uh a very important function of HDL and that is this thing called reverse cholesterol transport.
When there's inflammation that is driving cardiovascular disease, that reverse cholesterol fun uh cholesterol uh transport is not occurring. and the HDL particle remains small in in general.
So when reverse cholesterol transport is occurring that is when the HDL particles taking cholesterol back from the periphery to the liver which is a healthy function. Um in fact if I can just interrupt for one second just so people really understand what that means. You know H these H these big HDL particles are taking cholesterol from the periphery meaning even cholesterol plaques that have been on that are on the artery and removing them and bringing them to the liver.