The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
so your APO B goes up your LDL goes up when you eat saturated fat but is that pathological I would say no that's not pathological that's just your body responding to the changes in your fat intake to keep the membranes fluid
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
the fats that raise it are fats that you and I may believe to be healthy like saturated fats from butter or milk or eggs or meat which we've talked about in previous podcasts I believe are associated with human health but how can that be when they raise LDL cholesterol well maybe this level of LDL cholesterol is not the only metric to be looking at for your cardiovascular health and maybe it's not even a singly good metric to be looking out for your cardiovascular health maybe there are much more nuanced ways to think about this
the more saturated fat that I eat my LDL goes up maybe 10 to 15% when I'm eating Max saturated fat in my diet and this is just normal human physiology there's something called a homeoviscous model of adaptation that I won't get into in this podcast but I believe that the membranes of our cells probably shift in relationship to our fat composition and when we're eating more saturated fat the body has to make changes in the membranes to keep them at a certain level of fluidity and that requires LDL to go up a little bit to move cholesterol into the membranes of our cells