Higher rates of atrial fibrillation were observed with omega-3 fatty acid intake compared to placebo or corn oil in the Omey 1000 and Vital Rhythm studies.

“in a third trial omey one thousand and twenty seven older patients found that there was again an increase in the rates of atrial fibrillation the p-value was .06 perhaps not quite significant um but there was a an increase versus cornhill and the vital rhythm study published in this issue of jama this march 16 2021 issue of jama 12 thousand participants after a median of five point three years the incidence of atrial fibrillation was seven point two per one thousand persons and those taking omega six omega three fatty acids excuse me versus six point six to one thousand and those taking the placebo now this p value was not significant but again there was an increase”

“they say it's considered together data from these four trials suggest but do not prove there may be a dose-related risk of atrial fibrillation with omega-3 fatty acid intake at a dose of four grams per day there was a highly statistically significant increase in risk nearly a doubling with an intermediate dose of 1.8 grams per day the risk in the increase in risk did not achieve statistical significance and with a standard daily dose of 840 milligrams per day there was no apparent increase in risk although the data were consistent with as much as a 24 increase in risk”