Paul Saladino· MD
Even 1 hour of inactivity can lead to vascular dysfunction at the level of the endothelium (PMID: 25137367, 27443851).
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Even 1 hour of inactivity can lead to vascular dysfunction at the level of the endothelium (PMID: 25137367, 27443851).
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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Within a few hours of inactivity, the cells lining your blood vessels, the endothelium start to become a little dysfunctional and then we see markers of inflammation start to rise after three hours of being sedentary.