Andrew Huberman· PhD
Dynorphin is responsible for that dysphoric feeling when you're in the sauna and you're hot, and when you're running, doing exercise, and you feel uncomfortable.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Dynorphin is responsible for that dysphoric feeling when you're in the sauna and you're hot, and when you're running, doing exercise, and you feel uncomfortable.
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Our brain releases dynorphin - an opioid that is responsible for that dysphoric feeling but it also regulates our body's response to heat. But it also instigates biological feedback by sensitizing the mu-opioid receptors in the brain to beta-endorphins, the chemicals responsible for the euphoric post-exercise or sauna 'high.'