Merck marketed Vioxx as gentler on the stomach, and the Vigor trial was conducted to prove its safety and reduced GI complications.

“in 1999 the FDA didn't give them approval for uh being gentler on the stomach and Merck had was undertaking at the time Fox was approved they were undertaking another study called the Vigor trial to prove that Vox was a better drug because it was safer because it caused fewer serious GI complications so the box was originally approved in May 1999 and this study was published in the New England Journal in November of 2000 and it said that Merck significantly reduced the risk of uh serious upper GI yeah serious upper GI uh complications”