Is big pharma corrupt with John Abramson

PS

Paul Saladino1h 9m · 2022-10-04

Claims Made

125

Claims Supported

67

Support Rate

54%

Support rate

67 of 125 claims supported

67 supported58 partial / not

Claims from this content

41

Well SupportedLifestyle intervention with 150 minutes of weekly moderate-intensity exercise reduced diabetes incidence by 39%.Well SupportedHeart & Soil's 'Whole Package' supplement contains desiccated testicle, liver, and blood.Partially SupportedThe New England Journal of Medicine did not reveal missing data from the Vioxx Vigor trial, even though it was available through the FDA three months after publication.Partially SupportedNineteen out of twenty members of the 2020-2025 US dietary guidelines committee had ties to pharma and processed food companies.Partially Supported

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

For every serious GI complication prevented by Vioxx, three other serious adverse events, including cardiovascular events, were caused.

Partially SupportedTreating 100 people with Vioxx resulted in more adverse events like strokes and heart attacks than GI improvements.

Not SupportedDrugs targeting amyloid beta may cause more harm than good, and the amyloid hypothesis for Alzheimer's disease is likely incorrect.

Partially SupportedAttorneys won the right for broader cases against Pfizer regarding Neurontin marketing to proceed, with damages exceeding $300 million.

Partially SupportedDietary recommendations in the Diabetes Prevention Program Trial likely included stopping consumption of junk food and processed sugars.

Partially SupportedMerck marketed Vioxx as gentler on the stomach, and the Vigor trial was conducted to prove its safety and reduced GI complications.

Partially SupportedIn the Vioxx Vigor study, Vioxx was not gentler on the stomach compared to other anti-inflammatory drugs among people not taking steroids concurrently.

Partially SupportedNo study has been conducted comparing healthy lifestyle modification directly against statins for cardiovascular disease prevention.

Partially SupportedVioxx had a 1 in 40 user complication rate, was no more effective than older drugs, and cost significantly more.

Partially SupportedApproximately 60,000 people likely died due to Vioxx side effects, specifically clotting complications, cardiovascular events, and strokes.

Partially SupportedHormone replacement therapy significantly increases breast cancer risk in post-menopausal women.

Partially SupportedOne out of four new molecular entities approved by regulatory authorities provides substantial benefit over existing studies.

Partially SupportedAfter two months of taking 'Whole Package', Paul Saladino is stronger at age 52 than he was at age 32.

Partially SupportedThe median retail price for a new drug in 2022 was $250,000 per year, up from $3,000 in 2008.

Partially SupportedMedical students are not adequately taught about nutrition and lifestyle interventions, with a primary focus on drugs for treating diseases.

Partially SupportedThe Diabetes Prevention Program Trial randomized 3,234 non-diabetic individuals to placebo, Metformin (850mg twice daily), or lifestyle modification.

Not SupportedNeurontin (gabapentin) is frequently prescribed despite evidence of fraud and misleading study design by Pfizer.

Partially SupportedMetformin may suppress blood sugar without addressing underlying causes of diabetes complications like heart and kidney disease.

Partially SupportedHeart and Soil's 'Whole Package' supplement reversed testicular shrinkage and cessation of function caused by testosterone gel.

Partially SupportedData regarding adverse events, such as strokes and heart attacks, were omitted from Vioxx trial write-ups.

Partially SupportedThe Vioxx case involved manipulation of data to mislead physicians regarding its safety.

Partially SupportedPaul Saladino's pain, snoring, and itchy skin significantly improved after switching to an animal-based diet and taking Heart and Soil supplements.

Partially SupportedThe Diabetes Prevention Program Trial lifestyle modification program aimed for at least a 7% weight loss and 150 minutes of physical activity per week.

Partially SupportedUltra-processed foods like Snickers bars are associated with worse health outcomes, including cancers, diabetes, and the need for dialysis.

Partially SupportedThe Diabetes Prevention Program trial showed that lifestyle intervention reduced diabetes incidence by 58% compared to placebo in high-risk individuals, with benefits sustained over 10 years.

Not SupportedAn Alzheimer's drug that changes beta-amyloid in the brain has been approved by the FDA despite an advisory committee voting against approval due to potential harm.

Partially SupportedNeurontin (gabapentin) is one of the most frequently prescribed drugs in the US, despite legal findings of fraud.

Partially SupportedPharmacists should inform patients about the significant risks and side effects of prescribed drugs.

Partially SupportedEighty-six percent of medical trials are funded by pharmaceutical companies.

Partially SupportedHarvoni and Sovaldi are effective drugs for curing Hepatitis C.

Partially SupportedVioxx increases hyper-coagulability, leading to cardiovascular events.

Partially SupportedStudies of drugs intended to reduce heart disease risk should include a lifestyle intervention arm.

Partially SupportedPhysicians are taught to practice evidence-based medicine based on peer-reviewed articles.

Partially SupportedVioxx caused an estimated 40,000 to 60,000 American deaths.

Not SupportedVioxx caused serious adverse events in 1 in 40 users.

Not SupportedChantix advertisements should visually represent serious side effects and include data comparing psychiatric side effects to smoking cessation success rates.

Partially SupportedPreventative interventions can be twice as effective as first-line drugs for conditions like diabetes.