Paul Saladino· MD
the risk of thrombotic cardiovascular complications meaning as you said heart attacks blood clots and strokes together not individually together was significantly greater uh in vioxx than in Naprosyn which was the comparative drug
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
the risk of thrombotic cardiovascular complications meaning as you said heart attacks blood clots and strokes together not individually together was significantly greater uh in vioxx than in Naprosyn which was the comparative drug
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
you had to treat 125 people to prevent one serious GI complication but you're going to cause a serious adverse event in every 41 of out of every 40 people so for every GI complication that you prevented you're going to cause three other serious Adverse Events