Paul Saladino· MD
the diabetes prevention program trial is so striking the fact that you can give them one of the first line drugs that's very effective for diabetes Metformin and find that lifestyle intervention is better
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
the diabetes prevention program trial is so striking the fact that you can give them one of the first line drugs that's very effective for diabetes Metformin and find that lifestyle intervention is better
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the people who took metformin the the rightful first-line drug to treat type 2 diabetes — developed uh 31 uh less diabetes than the people who took Placebo
what's most striking about this study is that if you look at this lifestyle change was significantly better at reducing diabetes incidents than a drug metformin
the people in the lifestyle group 58 fewer people develop diabetes than the people who were treated with Placebo and that's for real
and I imagine there were some dietary recommendations which were probably at the level of stop eating junk food and processed sugars they're probably and that that level of intervention was significantly more effective than metformin which is which is striking
it was 300 3234 non-diabetic persons they had elevated fasting and post load plasma glucose concentrations and they were randomized to Placebo metformin and it was 850 milligrams twice daily or a lifestyle modification program
if you look at this lifestyle change was significantly better at reducing diabetes incidents than a drug metformin
the diabetes prevention program the dpp is an nih-funded study where metformin was one arm there was also a an arm of lifestyle changes and both of them were preventing diabetes in about 30 percent and by the way the study was stopped early because it was significant after four years
The largest study ever on diabetes prevention showed a lifestyle intervention with 150 minutes of weekly moderate-intensity exercise cut diabetes incidence by 39%, surpassing Metformin's effect.
A 20-year follow-up revealed a 24% reduction in diabetes incidence and a 3.5-year increase in diabetes-free survival for the exercise group, compared to 17% and 2.5 years for Metformin.
The largest study ever on diabetes prevention showed a lifestyle intervention with 150 minutes of weekly moderate-intensity exercise cut diabetes incidence by 39%, surpassing Metformin's effect.
A 20-year follow-up revealed a 24% reduction in diabetes incidence and a 3.5-year increase in diabetes-free survival for the exercise group, compared to 17% and 2.5 years for Metformin.