ApoB is likely sufficient in some cases, such as familial hypercholesterolemia, to cause atherosclerosis.

“I do think it's probably sufficient in some cases right that interesting uh that in FH for example uh it's probably sufficient in other words I don't think you have to have something else uh to get AO in in cases where the aob is Sky High”

“I think it's absolutely necessary I think the data really do suggest that if it's bottomed out absence some really bizarre probably monogenic things that we don't see very often that you can't get out there sclerosis”

“my belief is that be you know and we we should obviously talk about this I think that the epidemiology the clinical trial data and the mandelian randomization to my reading of this l and I don't think there's anything I pay closer attention to truthfully is that apob is a necessary but not sufficient criteria for atherosclerosis and as such removing it removes atherosclerosis”