The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
People who had LDL cholesterol naturally of 10 to 20 milligrams per deciliter, which would be an ApoB of about 20 milligrams per deciliter, and who never got heart disease. They were immune to heart disease, no matter how long they live.
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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In people who had hyper functioning PCSK9, this protein was just constantly hammering and destroying the LDL receptors. And so their LDL would be huge. And by extension, their total cholesterol would be.
but these patients walk around with LDL cholesterol of 10 to 20 milligrams per deciliter and as far as anybody can tell there's no other side effect of that
pcsk9 degrades LDL receptors so if you have a gain of function you are more rapidly degrading LDL receptors on the liver you're going to have a decrease in your clearance of LDL you will have a higher LDL
by inhibiting this protein by inhibiting the pcsk9 it prevents the LDL receptor degradation so that there is an upper regulation of LDL receptors on the surface of the hepatocyte which leads to Greater clearance of LDL out of circulation