Peter Attia· MD
low HDL cholesterol and high triglyceride turned out to be 4 times more predictive of MI than high LDL cholesterol
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
low HDL cholesterol and high triglyceride turned out to be 4 times more predictive of MI than high LDL cholesterol
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I mean the original epidemiology basically said you know you have to sort of applaud them for doing the best they could with the tools they had but let's take total cholesterol which was at the time the only thing we could measure clinically let's take the patients who were in the top 5% and the patients in the bottom 5% was there a difference in their risk of MI and the answer was yes right now it would be another at least decade until Framingham it's kind of an interesting story right how I got this this part of the story got ignored in Framingham was that low HDL cholesterol and high triglyceride turned out to be 4 times more predictive of MI than high LDL cholesterol
the LDL cholesterol which by the way was calculated not measured directly so you've introduced a very not in the first one to use correct it turned out to be less predictive than the ratio not the ratio I'm sorry the absolute level of HDL see and triglyceride