Peter Attia· MD
When those Pathways get overcome or less efficient the macrophage then builds up cholesterol and becomes the kind of foam cell that we're talking about
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
When those Pathways get overcome or less efficient the macrophage then builds up cholesterol and becomes the kind of foam cell that we're talking about
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macrophages have very well as established mechanisms for ridding themselves of cholesterol you know keep in mind no cell except the liver cell has the ability to metabolize cholesterol to other sterile species only the liver can do that cells can make plenty of cholesterol but the only way cells can deal with their cholesterol is to quote efflux the cholesterol to push the cholesterol out of the cell and get rid of it
macrophages need very very effective ways to rid themselves of cholesterol and they do have effective ways of doing that
that cholesterol ultimately has to come out of those cells into something this is where HDL comes in and ultimately get back to the liver where the liver then can metabolize it or directly excrete it into the bile then it goes out the intestine and the feces