Nicotine ingestion via non-smoking/vaping routes bypasses some endothelial cell function disruptions but still causes penile girth reduction and reduced tissue blood flow.

“But when people ingest nicotine acutely, and let's say they do that by Nicorette patch or by toothpick dipped in nicotine, it will have some of these same effects, but when not smoking tobacco, when bringing nicotine into the bloodstream through other mechanisms, many, if not all of the disruption of the endothelial cell function can be bypassed, but the effects on penile girth, the effects on reducing blood flow to various tissues is still present during the effects of nicotine, which as I mentioned last about one to two hours.”