Paul Saladino· MD
If your cholesterol goes up, I'm not worried about it as long as you remain insulin sensitive.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
If your cholesterol goes up, I'm not worried about it as long as you remain insulin sensitive.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
and the question is do they accumulate atherosclerosis at the same level as someone with an equivalent ldl who might be diabetic or less metabolically healthy and that's a fascinating question because if the answer is no then the mainstream ldl paradigm needs revision and that will change the face of medicine because so many things in medicine are based around ldl
I think this is because of these mandelian randomization relationships between LDL and cardiovascular disease