The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
some people genetically have low hdl and they are perfectly insulin sensitive and do not develop atherosclerosis and a lot of the drugs these see the cetp inhibitors that were developed to raise hdl were they were complete catastrophes
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
The genes associated with variation in HDL cholesterol have, almost in every case, not been associated with heart disease risk, and that is another argument that has sort of cast the HDL in a somewhat different light than LDL, certainly as a target for therapeutic intervention.
Genes associated with high LDL are associated with heart disease risk. That's a very important pathologic connection because genes ultimately are the blueprint for our biology. And if the genes associated with high LDL are also associated with heart disease risk, it says that the LDL is really the causal agent.