David Sinclair· PhD
Each 1 mmol/L (≈38.7 mg/dL) higher LDL-C raised the risk of MI by 26% and CHD events by 28%.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Each 1 mmol/L (≈38.7 mg/dL) higher LDL-C raised the risk of MI by 26% and CHD events by 28%.
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you have to understand what an independent risk factor means it means that all things being equal are you better off having higher HDL yeah but HDL is more of a marker of metabolic health because we have some drug trials and mendelian randomizations now where they modulate HDL and it doesn't really seem to make a difference whereas if you modulate LDL so even at high HDL or low HDL in both stratifications lower LDL is almost always better for cardiovascular disease and mortality
for every 1 mill mole reduction in LDL or >> which is about 37 milligrams per deciliter. >> It's 39.4 milligrams per deciliter. Yeah. >> There was a 50 to 55% risk reduction in cardiovascular disease.