Paul Saladino· MD
we're sisters and a brother in their 60s with lifelong mega LDL as in from memory around 350 LDL alone milligrams two of them with zero CAC and the third one same but also got an angio for other reasons and was clear
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
we're sisters and a brother in their 60s with lifelong mega LDL as in from memory around 350 LDL alone milligrams two of them with zero CAC and the third one same but also got an angio for other reasons and was clear
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
to the best of my knowledge this is the first one I don't know of any study that does specifically exclude any form of dysfunction or abnormality with the intention of looking at metabolically healthy uh folks with extreme prospectively look at metabolically healthy folks with extremely high levels of LDL and the outcome of plaque formation full stop
we're seeing people where LDL is super high and they're not having the they're not having high plaque burdens they're not seeing increased risk of cardiovascular disease